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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: However, CAR T cells have achieved minimal success against solid malignancies because of the additionalon the recent advances in the engineering of CAR T cell therapies to restore the immune response in solidmalignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators towith biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: The current standard of care in hematological malignancies has brought considerable clinical benefitsantigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematological malignancies

Keywords： CAR T cells     hematological malignancies     review    

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cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 108-115 doi: 10.1007/s11684-019-0730-8

Abstract: Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloidafter myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoid malignancies

Keywords： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract:

To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide.

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 468-477 doi: 10.1007/s11684-015-0419-6

Abstract:

Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathologicalBone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies comparedclinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignanciescharacteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid malignancies

Keywords： mature T-cell lymphoid malignancies     clonal T-cell population     bone marrow infiltration     prognostic factors    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 365-377 doi: 10.1007/s11684-018-0641-0

Abstract: Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies

Keywords： invasive fungal diseases     hematological malignancies     chemotherapy     risk score     prophylaxis    

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Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis

Frontiers in Energy doi: 10.1007/s11708-023-0901-9

Abstract: Interconnector is a critical component to construct solid oxide cells (SOCs) stack.

Keywords： interconnector coating     plasma spray     electrochemical performance     Cr diffusion inhibition     solid oxide    

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: techniques, and strategies for the detection of cancer, and emphasizes the application of MRD detection in solid

Keywords： MRD     solid tumor     CTC     ctDNA    

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High-solid anaerobic digestion of sewage sludge: achievements and perspectives

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1364-4

Abstract:

• High-solid anaerobic digestion (HS-AD) of sewage sludge (SS) is overviewed

Keywords： High-solid effect     Anaerobic fermentation     Methane production     Biodegradability     Sludge treatment    

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Review of SO42-/MxOy solid superacid catalysts

Yanni WU, Shijun LIAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 330-343 doi: 10.1007/s11705-009-0208-3

Abstract: solid superacid catalysts, play a vital role in more and more fields such as organic synthesis, fineThis review highlights the recent development of solid superacid catalysts based on , including synthesis

Keywords： solid superacid catalyst     synthesis method     characterization     applications    

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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1407-5

Abstract:

• Implication of COVID-19 on medical waste and MSW generation is studied.

Keywords： COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

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Municipal solid waste management in Dalian: practices and challenges

Xinbei WANG, Yong GENG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 4,   Pages 540-548 doi: 10.1007/s11783-011-0361-z

Abstract: The fast growing of urban areas in developing countries has brought serious problems on municipal solid

Keywords： municipal solid waste (MSW) management     3R principles     challenges     eco-efficiency     effective and efficient    

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Lagrangian simulation of deposition of CO gas-solid sudden expansion flow

HUANG Dongping, DING Guoliang, QUACK Hans

Frontiers in Energy 2008, Volume 2, Issue 2,   Pages 216-221 doi: 10.1007/s11708-008-0032-3

Abstract: Freezing and blockage resulting from the deposition of solid CO formed because of sudden expansion ofTo overcome this problem, the characteristics of the CO gas-solid sudden expansion flow are studied byA comparison of the calculated deposition of the solid CO with the experimental results shows that theyThe simulation results show that the size of the solid CO formed should not be in the range of 0.04–0.07

Keywords： comparison     gas-solid     downstream     blockage     Lagrangian    

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Development and prospects of municipal solid waste (MSW) incineration in China

NIE Yongfeng

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 1-7 doi: 10.1007/s11783-008-0028-6

Abstract: With the lack of space for new landfills, municipal solid waste (MSW) incineration is playing an increasinglyimportant role in municipal solid waste management in China.

Keywords： development     management     municipal     MSW     incineration    

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Title Author Date Type Operation

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Journal Article

cyclophosphamide for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:

Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

Journal Article

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis

Journal Article

Minimal residual disease in solid tumors: an overview

Journal Article

High-solid anaerobic digestion of sewage sludge: achievements and perspectives

Journal Article

Review of SO42-/MxOy solid superacid catalysts

Yanni WU, Shijun LIAO

Journal Article

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Journal Article

Municipal solid waste management in Dalian: practices and challenges

Xinbei WANG, Yong GENG

Journal Article

Lagrangian simulation of deposition of CO gas-solid sudden expansion flow

HUANG Dongping, DING Guoliang, QUACK Hans

Journal Article

Development and prospects of municipal solid waste (MSW) incineration in China

NIE Yongfeng

Journal Article